1-Boc-4-羟基-4-(羟基甲基)-哌啶合成路线 （共 7 条）
反应条件
water; 4-methylmorpholine N-oxide; osmium(VIII) oxide in tetrahydrofuran
T=0°C; 2 h;
参考文献
Ogino, Yoshio; Kurihara, Hideki; Matsuda, Kenji; Numazawa, Tomoshige; Otake, Norikazu; Noguchi, Kazuhito
Patent: US2003/191316 A1, 2003 ;
Location in patent: Page/Page column 36 ;
反应条件
triethylamine in methanol
T=20°C;
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 194; 195 ;
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 197 ;
反应条件
1.1: sodium hydride; tetrabutylammomium bromide / dimethyl sulfoxide / 1 h / 0 °C
1.2: 1.5 h / 20 °C
2.1: sulfuric acid / 20 °C
3.1: palladium hydroxide on carbon; hydrogen / methanol / 775.74 Torr
4.1: triethylamine / methanol / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
1: sulfuric acid / 20 °C
2: palladium hydroxide on carbon; hydrogen / methanol / 775.74 Torr
3: triethylamine / methanol / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
1.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.2: 0.5 h / 20 °C
3.1: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
1.2: 0.5 h / 20 °C
2.1: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
