2-环戊基-2-羟基-2-噻吩-2-基乙酸合成路线 （共 4 条）
反应条件
1: cyclopentyl-bromide With magnesium; iodine in diethyl ether
0.5 h;
2: 2-oxo-2-thien-2-ylacetic acid With sodium hydride in diethyl ether
T=0 - 20°C; 4 h;
3: With water in diethyl ether
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/66929 A1, 2006 ;
Location in patent: Page/Page column 40 ;
WO 2006/066929 A1
反应条件
potassium hydroxide; ethanol
T=20°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/117754 A1, 2006 ;
Location in patent: Page/Page column 20 ;
WO 2006/117754 A1
反应条件
hydrogenchloride; sodium chloride; sodium hydrogencarbonate in tetrahydrofuran; diethyl ether
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5750540 A1, 1998 ;
参考文献
Prat Quinones, Maria; Fernandez Forner, Maria Dolors; Buil Albero, Maria Antonia
Patent: US2004/72863 A1, 2004 ;
