6-甲氧基-2-乙酰萘合成路线 （共 124 条）
反应条件
1: 100 percent / H2 / 5 percent Pd/C / tetrahydrofuran
2: 93 percent Chromat. / PdCl2, CuCl2, TFA, 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-L-iditol / butan-2-one / 100 °C / 600048 Torr
View Scheme
参考文献
Xie, Bao-Han; Xia, Chun-Gu; Lu, Shi-Jie; Chen, Ke-Jun; Kou, Yuan; Yuan-Qi, Yin
Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7365 - 7368
反应条件
(i) LiAlH4, (ii) SOCl2; Multistep reaction;
参考文献
Tsuno,Y. et al.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 3033 - 3042
反应条件
1: 83 percent / aq. NaClO; NaOH / dioxane / 48 h / 90 °C
2: 96 percent / LiAlH4 / tetrahydrofuran / 8 h / 20 °C
3: PBr3 / tetrahydrofuran / -40 - 20 °C
View Scheme
参考文献
Shi, Zhen-Dan; Yang, Bing-Hui; Zhao, Jing-Jing; Wu, Yu-Lin; Ji, Yong-Yong; Yeh, Ming
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2171 - 2175
反应条件
hydrogenchloride in dimethyl sulfoxide; ethyl acetate
参考文献
Beecham Group Limited
Patent: US4221741 A1, 1980 ;
反应条件
1: With potassium sec-butoxide in dimethyl sulfoxide
T=50 - 60°C; 1 h;
2: With hydrogenchloride in water; dimethyl sulfoxide
pH=2; Reagent/catalyst;
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
反应条件
1: acetic acid; hydrogen bromide / water / 12 h / 100 °C
2: Na2S2O5; ammonium hydroxide / water / 96 h / 100 °C
View Scheme
参考文献
Shin, Sung Min; Lee, Mi Sun; Han, Ji Hee; Jeong, Nakcheol
Chemical Communications, 2014 , vol. 50, # 3 p. 289 - 291
反应条件
1: 4 g / acetic acid / 24 h / Heating
2: 100 percent / H2 / Pd/C / tetrahydrofuran
3: 80 percent / p-toluenesulfonic acid / benzene / 10 h / Heating
View Scheme
参考文献
Cavrini; Roveri; Gatti; Ferruzzi; Panico; Pappalardo
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 3 p. 171 - 178
反应条件
1.1: potassium sec-butoxide / dimethyl sulfoxide / 1 h / 50 - 60 °C
1.2: pH 2
2.1: hydrogen; palladium 10 on activated carbon; sulfuric acid / ethyl acetate
View Scheme
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
反应条件
1: 1-(6-methoxy-2-naphthyl)-1-ethanone With sodium ethanolate in diethyl ether
T=20°C; 0.25 h;
2: formic acid ethyl ester in diethyl ether
T=20°C; 3 h;
3: ethyl bromide in diethyl ether
T=20°C; 24 h; Further stages.;
参考文献
Stern, Eric; Muccioli, Giulio G.; Bosier, Barbara; Hamtiaux, Laurie; Millet, Regis; Poupaert, Jacques H.; Henichart, Jean-Pierre; Depreux, Patrick; Goossens, Jean-Francois; Lambert, Didier M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5471 - 5484
参考文献
Das, Swati; Bhattachryya, Sukanta; Mukherjee, Debabrata
Tetrahedron, 1992 , vol. 48, # 41 p. 9101 - 9110
