6-甲氧基-2-乙酰萘合成路线 （共 124 条）
反应条件
sodium hydrogencarbonate in toluene
T=80°C; 12 h; Molecular sieveInert atmosphere;
参考文献
Pei, Dong; Zhang, Yu; Wei, Siyu; Wang, Meng; Sun, Jian
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 4 p. 619 - 623
反应条件
1.1: potassium sec-butoxide / dimethyl sulfoxide / 1 h / 50 - 60 °C
1.2: pH 2
2.1: acetic acid; hydrogen; palladium on activated charcoal / 20 °C
View Scheme
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
反应条件
1.1: potassium sec-butoxide / dimethyl sulfoxide / 1 h / 50 - 60 °C
1.2: pH 2
2.1: hydrogen; palladium 10 on activated carbon; sulfuric acid / ethyl acetate
View Scheme
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
反应条件
2-carboxyethyl triphenyl phosphonium tribromide in tetrahydrofuran
T=25°C; 6 h;
参考文献
Cristau, Henri-Jean; Torreilles, Eliane; Morand, Philippe; Christol, Henri
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 25, p. 357 - 368
反应条件
toluene-4-sulfonic acid; sulfur
T=130°C; Willgerodt-Kindler reaction; 45 h;
参考文献
Andrus, Merritt B.; Harper, Kaid C.; Christiansen, Michael A.; Binkley, Meisha A.
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4541 - 4544
参考文献
Nasipuri,D.; Roy,J.
Journal of the Chemical Society, 1960 , p. 1571 - 1575
反应条件
in ethanol
Mannich reaction; Reflux;
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
参考文献
Guette,M.; Lucas,M.
Bulletin de la Societe Chimique de France, 1975 , p. 2759 - 2762
反应条件
1: 83 percent / aq. NaClO; NaOH / dioxane / 48 h / 90 °C
2: 96 percent / LiAlH4 / tetrahydrofuran / 8 h / 20 °C
View Scheme
参考文献
Shi, Zhen-Dan; Yang, Bing-Hui; Zhao, Jing-Jing; Wu, Yu-Lin; Ji, Yong-Yong; Yeh, Ming
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2171 - 2175
反应条件
1: NaBrO
2: aqueous HBr
3: aq.-ethanolic KOH
View Scheme
参考文献
Gray; Jones
Journal of the Chemical Society, 1954 , p. 678,682
