6-甲氧基-2-乙酰萘合成路线 （共 124 条）
反应条件
aluminium trichloride in 1,2-dichloro-ethane T=40°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Pivsa-Art, Sommai; Okuro, Kazumi; Miura, Masahiro; Murata, Satoru; Nomura, Masakatsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1703 - 1708
反应条件
ethanol; horse liver alcohol dehydrogenase; NADH dipotassium salt in tetrahydrofuran pH=8; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Galletti, Paola; Emer, Enrico; Gucciardo, Gabriele; Quintavalla, Arianna; Pori, Matteo; Giacomini, Daria
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4117 - 4123
反应条件
1: oxygen; 1,1'-azobis (cyclohexanecarbonitrile) / 6 h / 105 °C 2: sulfuric acid / acetone / Heating 3: sulfuric acid / 6 h / 79 - 82 °C 4: copper acetylacetonate; 2-hydroxy-1,3-isoindolinedione; 2,2'-azo-bisisobutyronitrile / benzonitrile / 0.83 h / 70 °C View Scheme
参考文献
Orlinska, Beata; Stec, Zbigniew; Zawadiak, Jan
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 295 - 301
反应条件
1: sulfuric acid / 6 h / 79 - 82 °C 2: copper acetylacetonate; 2-hydroxy-1,3-isoindolinedione; 2,2'-azo-bisisobutyronitrile / benzonitrile / 0.83 h / 70 °C View Scheme
参考文献
Orlinska, Beata; Stec, Zbigniew; Zawadiak, Jan
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 295 - 301
反应条件
1: sulfuric acid / acetone / Heating 2: sulfuric acid / 6 h / 79 - 82 °C 3: copper acetylacetonate; 2-hydroxy-1,3-isoindolinedione; 2,2'-azo-bisisobutyronitrile / benzonitrile / 0.83 h / 70 °C View Scheme
参考文献
Orlinska, Beata; Stec, Zbigniew; Zawadiak, Jan
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 295 - 301
反应条件
T=475 - 500°C; vapor-phase pyrolysis; Yield given;
参考文献
Zoeller, Joseph R.
Tetrahedron Letters, 1989 , vol. 30, # 12 p. 1457 - 1460
反应条件
1: 99 percent / KOH / H2O; ethanol / 5 h / 100 °C 2: 1) LDA / 1) hexane, THF, 0 deg C, 30 min, 2) HMPA, -78 deg C -> 0 deg C, 1 h 3: 1) Mg / 1) diethyl ether, 2) rt, 2 h 4: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 5: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 6: 53 percent / DDQ / benzene / 4.7 h / Heating 7: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 8: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 9: 35 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Shishido, Kozo; Yamashita, Akitake; Hiroya, Kou; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 469 - 475
反应条件
1: 1) LDA / 1) hexane, THF, 0 deg C, 30 min, 2) HMPA, -78 deg C -> 0 deg C, 1 h 2: 1) Mg / 1) diethyl ether, 2) rt, 2 h 3: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 4: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 5: 53 percent / DDQ / benzene / 4.7 h / Heating 6: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 7: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 8: 35 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Shishido, Kozo; Yamashita, Akitake; Hiroya, Kou; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 469 - 475
反应条件
1.1: 2-hydroxy-1,3-isoindolinedione; 2,2'-azo-bisisobutyronitrile; oxygen / benzonitrile / 5 h / 60 °C 1.2: 0 °C 2.1: copper acetylacetonate; 2-hydroxy-1,3-isoindolinedione / 2.5 h / 70 °C View Scheme
参考文献
Orlinska, Beata; Stec, Zbigniew; Zawadiak, Jan
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 295 - 301
反应条件
1: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 2: 35 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Shishido, Kozo; Yamashita, Akitake; Hiroya, Kou; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 469 - 475
