6-甲氧基-2-乙酰萘合成路线 （共 124 条）
反应条件
1.1: potassium sec-butoxide / dimethyl sulfoxide / 1 h / 50 - 60 °C 1.2: pH 2 2.1: hydrogen; palladium 10 on activated carbon; sulfuric acid / ethyl acetate View Scheme
参考文献
Prabhakar; Reddy, C. Bakki; Reddy, Ch. Maheedhara; Nageshwar; Devi, A. Sivalakshmi; Babu, J. Moses; Vyas; Sarma; Reddy
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 121 - 125
反应条件
1: sulfur; morpholine / 140 °C / Erhitzen des Reaktionsgemisches mit Essigsaeure und wss. Salzsaeure 2: sulfuric acid View Scheme
参考文献
Jones et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2843,2945
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium in toluene
参考文献
Petric, Andrej; Jacobson, Andrew F.; Barrio, Jorge R.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1455 - 1460
反应条件
1: aq. HCl / Heating 2: NaHSO3 View Scheme
参考文献
Petric, Andrej; Jacobson, Andrew F.; Barrio, Jorge R.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1455 - 1460
反应条件
1: hydrogen bromide / dichloromethane / 2 h / 90 °C 2: potassium metabisulfite / water / 48 h / 140 °C / Autoclave 3: pyridine / 36 h / 110 °C View Scheme
参考文献
Cui, Mengchao; Tang, Ruikun; Li, Zijing; Ren, Huiying; Liu, Boli
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1064 - 1068
反应条件
Oxonereg;; NH4Br in methanol T=20°C; 0.666667 h; regioselective reaction;
参考文献
MacHarla, Arun Kumar; Chozhiyath Nappunni, Rohitha; Marri, Mahender Reddy; Peraka, Swamy; Nama, Narender
Tetrahedron Letters, 2012 , vol. 53, # 2 p. 191 - 195
反应条件
2-carboxyethyl triphenyl phosphonium tribromide in tetrahydrofuran T=25°C; 24 h; Further byproducts given;
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 25, p. 357 - 368
反应条件
1: 86 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / hexane / 16 h / 20 °C 2: conc. sulfuric acid; bromine / tetrahydrofuran / 4 h / 20 °C 3: 110 mg / diethyl phosphite; DIPEA / tetrahydrofuran / 20 °C View Scheme
参考文献
Nitz, Mark; Mezo, Adam R; Ali, Mayssam H; Imperiali, Barbara
Chemical communications (Cambridge, England), 2002 , # 17 p. 1912 - 1913
反应条件
1: dimethyl amine With lithium in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene T=20°C; 1.5 h; 2: 1-(6-methoxy-2-naphthyl)-1-ethanone in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene T=20°C; 20 h;
参考文献
Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.
Patent: US2007/53831 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
N,N'-dimethyl-N,N'-propyleneurea in hexane T=20°C; 16 h;
参考文献
Nitz, Mark; Mezo, Adam R; Ali, Mayssam H; Imperiali, Barbara
Chemical communications (Cambridge, England), 2002 , # 17 p. 1912 - 1913
