3-beta-D-呋喃核糖基咪唑并(2,1-i)嘌呤合成路线 （共 10 条）
反应条件
(NH4)2S2O8 T=80°C; 4 h; pH 7.2 (phosphate buffer); other 1,N6-adenosine derivates; Mechanism;
参考文献
Sako; Hayashi; Hirota; Maki
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 6 p. 1656 - 1658
反应条件
N-methylmorpholine acetate
T=37°C; 120 h; pH = 9.2;
参考文献
Guengerich, F. Peter; Raney, Veronica M.
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1074 - 1080
反应条件
sodium hydroxide in water
T=60°C; 72 h; at pH 4.5;
参考文献
Nair, Vasu; Offerman, Rick J.; Turner, Gregory A.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4021 - 4025
反应条件
1: 144 h / Ambient temperature; pH 4.5
2: E. coli alkaline phosphatase
3: calf spleen phosphodiesterase
View Scheme
参考文献
Inoue, Yasuo; Kuramochi, Takao; Sakurai, Michiharu; Tazawa, Ichiro
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5574 - 5577
反应条件
Calf spleen phosphodiesterase
参考文献
Inoue, Yasuo; Kuramochi, Takao; Sakurai, Michiharu; Tazawa, Ichiro
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5574 - 5577
反应条件
in N,N-dimethyl-formamide
T=20°C; Cyclization; 4.5 h;
参考文献
Kronberg, Leif; Asplund, Deanne; Maeki, Jukka; Sjoeholm, Rainer
Chemical Research in Toxicology, 1996 , vol. 9, # 8 p. 1257 - 1263
反应条件
sodium hydroxide
T=37°C; pH=4.2; 26 h;
参考文献
Patching, Simon G.; Baldwin, Stephen A.; Baldwin, Alexander D.; Young, James D.; Gallagher, Maurice P.; Henderson, Peter J. F.; Herbert, Richard B.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 462 - 470
反应条件
in water
T=60°C; Condensation; cyclization; pH=4.7; Kinetics; Further Variations:pH-valuesaldehyde conc.;
参考文献
Mikkola, Satu; Koissi, Niangoran; Ketomaeki, Kaisa; Rauvala, Susanna; Neuvonen, Kari; Loennberg, Harri
European Journal of Organic Chemistry, 2000 , # 12 p. 2315 - 2323
反应条件
in water
T=60°C; Condensation; cyclization; pH=4.7; Kinetics; Further Variations:pH-valuesaldehyde conc.;
参考文献
Mikkola, Satu; Koissi, Niangoran; Ketomaeki, Kaisa; Rauvala, Susanna; Neuvonen, Kari; Loennberg, Harri
European Journal of Organic Chemistry, 2000 , # 12 p. 2315 - 2323
反应条件
sodium hydroxide
T=60°C; 10 h;
参考文献
Maeki, Jukka; Sjoeholm, Rainer; Kronberg, Leif
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000 , # 24 p. 4445 - 4450
