4,5‘,8-三甲基]补骨脂素合成路线 （共 16 条）
参考文献
Kim, Kwonil; Matsuura, Kazunori; Kimizuka, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4311 - 4317
反应条件
trifluorormethanesulfonic acid; trifluoroacetic acid in dichloromethane; chloroform
参考文献
Elder Pharmaceuticals, Inc.
Patent: US4950770 A1, 1990 ;
反应条件
trifluorormethanesulfonic acid; trifluoroacetic acid in dichloromethane
6 h; Ambient temperature;
参考文献
Heindel; Choudhuri; Ressner; Foster
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 73 - 76
反应条件
in acetic acid
T=20°C; 15 h; Protected from light;
参考文献
Marker Gene Technologies, Inc.
Patent: US6656917 B1, 2003 ;
Location in patent: Page column 15 ;
反应条件
1: acetic acid
2: 6 h / Heating
View Scheme
参考文献
Wulff, Heike; Rauer, Heiko; Duering, Tim; Hanselmann, Christine; Ruff, Katharina; Wrisch, Anja; Grissmer, Stephan; Haensel, Wolfram
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4542 - 4549
反应条件
1: 61 percent / trifluoromethanesulfonic acid, trifluoroacetic acid / CH2Cl2 / 6 h / Ambient temperature
2: 80 percent / 85percent aq. hydrazine / ethanol / 6 h / Heating
View Scheme
参考文献
Heindel; Choudhuri; Ressner; Foster
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 73 - 76
