1-甲基-1氢-5-醛基-咪唑合成路线 （共 26 条）
反应条件
in dichloromethane T=-78 - 20°C; 2 h;
参考文献
Perez, Michel; Lamothe, Marie; Hill, Bridget; Etievant, Chantal
Patent: US2004/204417 A1, 2004 ;
Location in patent: Page 31 ;
US 20040204417 A1
反应条件
manganese(IV) oxide in chloroform 23 h; Heating;
参考文献
Zarghi; Ebrahimabadi; Hassanzadeh; Heydari; Shafiee
Bollettino Chimico Farmaceutico, 2003 , vol. 142, # 6 p. 251 - 254
反应条件
hydrogen; ammonium formate; palladium on activated charcoal in methanol Heating;
参考文献
Shapiro; Gomez-Lor
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5524 - 5526
反应条件
1: 71 percent / NaNO2; aq. HNO3 / 0.75 h 2: 95 percent / MnO2 / CHCl3 / 12 h / Heating View Scheme
参考文献
Collman, James P.; Zhong, Min; Costanzo, Simona; Zhang, Chi
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8252 - 8256
反应条件
sodium carbonate; glycerol T=170°C;
参考文献
Jones; McLaughlin
Journal of the American Chemical Society, 1949 , vol. 71, p. 2444,2447
反应条件
1: 1H-imidazole-5-carbaldehyde With triethylamine; benzenesulfonyl chloride in acetonitrile 8 h; Inert atmosphere; 2: methyl trifluoromethanesulfonate in acetonitrile 24 h; Inert atmosphere; 3: With N-methyl-N-butylamine in acetonitrile T=80°C; Inert atmosphereHeating; regioselective reaction;
参考文献
Van Den Berge, Emilie; Robiette, Raphael
Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12220 - 12223
反应条件
1: 5-iodo-1-methyl-1H-imidazole With ethylmagnesium bromide in dichloromethane T=20°C; 1 h; 2: N,N-dimethyl-formamide in dichloromethane T=0 - 22°C; Further stages.;
参考文献
Holden, Kenneth G; Mattson, Matthew N; Cha, Kyung Hoi; Rapoport, Henry
The Journal of organic chemistry, 2002 , vol. 67, # 17 p. 5913 - 5918
反应条件
1: 1H-imidazole-4-carbaldehyde With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Oresmaa, Larisa; Taberman, Helena; Haukka, Matti; Vainiotalo, Pirjo; Aulaskari, Paula
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1445 - 1451
反应条件
1: 80 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / -10 - 36 °C 2: MnO2 / tetrahydrofuran / Heating View Scheme
参考文献
Jones; McLaughlin
Journal of the American Chemical Society, 1949 , vol. 71, p. 2444,2447
反应条件
n-butyllithium in tetrahydrofuran T=-70°C; Yield given. Yields of byproduct given;
参考文献
Shapiro, Gideon; Marzi, Martin
Tetrahedron Letters, 1993 , vol. 34, # 21 p. 3401 - 3404
