(2,5-二氧代吡咯烷-1-基)4-碘苯甲酸酯合成路线 （共 7 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide; toluene 24 h; Inert atmosphereReflux;
参考文献
Carroll, Michael Andrew; Yan, Ran
Patent: US2009/286992 A1, 2009 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Carroll, Michael Andrew; Yan, Ran
Patent: US2009/286992 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane
2 h; Heating;
参考文献
Shell, Thomas A.; Mohler, Debra L.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 17 p. 3091 - 3093
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
T=75°C; 0.75 h;
参考文献
Khalaj, Ali; Beiki, Davood; Rafiee, Hamid; Najafi, Reza
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 3 p. 235 - 240
反应条件
1.1: sodium nitrite; hydrochloric acid / H2O / 0.33 h / 0 °C
1.2: 80 percent / potassium hydroxide / H2O / 0.17 h
2.1: 95 percent / dicyclohexyl carbodiimide / tetrahydrofuran / 20 °C
3.1: 90 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 0.75 h / 75 °C
View Scheme
参考文献
Khalaj, Ali; Beiki, Davood; Rafiee, Hamid; Najafi, Reza
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 3 p. 235 - 240
反应条件
1: 95 percent / dicyclohexyl carbodiimide / tetrahydrofuran / 20 °C
2: 90 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 0.75 h / 75 °C
View Scheme
参考文献
Khalaj, Ali; Beiki, Davood; Rafiee, Hamid; Najafi, Reza
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 3 p. 235 - 240
反应条件
in dichloromethane
T=20°C; 13.5 h;
参考文献
Li, Jie; Lin, Shixian; Wang, Jie; Jia, Shang; Yang, Maiyun; Hao, Ziyang; Zhang, Xiaoyu; Chen, Peng R.
Journal of the American Chemical Society, 2013 , vol. 135, # 19 p. 7330 - 7338
