1-(2-氨基-4-氯苯基)乙酮合成路线 （共 14 条）
反应条件
1: 75 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 95 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 3: 98 percent / NaI; Et3N / acetonitrile / 1 h / Heating 4: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 5: 81 percent / aq. NaOH / methanol / Heating View Scheme
参考文献
Landquist
Journal of the Chemical Society, 1951 , p. 1038,1046
反应条件
1: 75 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 95 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 3: 98 percent / NaI; Et3N / acetonitrile / 1 h / Heating 4: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 5: 81 percent / aq. NaOH / methanol / Heating 6: 94 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Theeraladanon, Chumpol; Arisawa, Mitsuhiro; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron, 2004 , vol. 60, # 13 p. 3017 - 3035
反应条件
2: sulfuric acid; nitric acid 3: aq.-ethanolic hydrochloric acid 4: aqueous HCl; aqueous H3PO2 / 0 °C View Scheme
参考文献
Atkinson; Simpson
Journal of the Chemical Society, 1947 , p. 232,236
反应条件
2: sulfuric acid; nitric acid 3: aq.-ethanolic hydrochloric acid 4: aqueous HCl / anschliessendes Behandeln mit wss. H3PO2 bei 0grad View Scheme
参考文献
Atkinson; Simpson
Journal of the Chemical Society, 1947 , p. 232,236
反应条件
1: With trifluoroacetic acid in dichloromethane
T=20°C;
2: With sodium hydroxide in dichloromethane
参考文献
SANOFI-AVENTIS
Patent: US2011/144115 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
1: in tetrahydrofuran; diethyl ether
T=0 - 25°C; 3.33333 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water
T=-60 - 18°C; 3 h;
3: With potassium hydroxide in water
pH=9; Product distribution / selectivity;
参考文献
Cheung, Adrian Wai-Hing; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Mertz, Eric; Qi, Lida; Qian, Yimin; Scott, Nathan Robert
Patent: US2012/258982 A1, 2012 ;
Location in patent: Page/Page column 43 ;
US 20120258982 A1
反应条件
in ethylene glycol dimethyl ether; ethylene glycol diethyl ether
T=0°C; 2 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
反应条件
1: With sulfuric acid
T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique;
2: With sodium hydrogencarbonate
Inert atmosphereSchlenk technique;
参考文献
Bhanuchandra; Ramu Yadav; Rit, Raja K.; Rao Kuram, Malleswara; Sahoo, Akhila K.
Chemical Communications, 2013 , vol. 49, # 45 p. 5225 - 5227
反应条件
1: acetic acid
2: phosphorus (V)-chloride; benzene / Erhitzen des Reaktionsprodukts mit wss. Bromwasserstoffsaeure
View Scheme
参考文献
Atkinson; Simpson
Journal of the Chemical Society, 1947 , p. 232,236
反应条件
1: tetrahydrofuran / -40 - 20 °C
2: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/144115 A1, 2011 ;
