2-氯-6-甲基烟酸乙酯合成路线 （共 10 条）
反应条件
potassium acetate; triethylamine; phosphorus trichoride in N,N-dimethyl-formamide; toluene
参考文献
Reilly Industries, Inc.
Patent: US5493028 A1, 1996 ;
反应条件
thionyl chloride in dichloromethane Reflux;
参考文献
ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon
Patent: WO2013/14587 A1, 2013 ;
Location in patent: Page/Page column 746 ;
WO 2013/014587 A1
反应条件
1: H2SO4 2: PCl5, POCl3 View Scheme
参考文献
Abbott Laboratories
Patent: US5250548 A1, 1993 ;
US 5250548 A
参考文献
ACTELION PHARMACEUTICALS LTD.; Hilpert, Kurt; Hubler, Francis; Kimmerlin, Thierry; Renneberg, Dorte; Stamm, Simon; Murphy, Mark
Patent: US2014/163035 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: potassium acetate, Et3N / toluene / 1.) 5 deg C, 30 min; 2.) RT, 6 h 2: PCl3, HCl(g) / dimethylformamide; toluene / 1.) 65 deg C, 10 min; 2.) 80 deg C, 1 h View Scheme
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
1: AcOH / ethanol / Heating 2: 31 percent / aq. HCl, NaNO2 / 3 h / Ambient temperature View Scheme
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
反应条件
hydrogenchloride; sodium nitrite 3 h; Ambient temperature;
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
McCombie, Stuart W.; Lin, Sue-Ing; Tagat, Jayaram R.
Heterocycles, 1993 , vol. 35, # 1 p. 93 - 97
反应条件
1: 52 percent / dimethylformamide / 8 h / Heating 2: 68 percent / aq. NaOH / methanol / 1 h / Ambient temperature 3: diphenylphosphoric azide, Et3N / 2-methyl-propan-2-ol / 3 h / Heating 4: H2O / 1 h / Heating View Scheme
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
反应条件
sodium hydrogensulfide in ethanol
参考文献
McCombie, Stuart W.; Lin, Sue-Ing; Tagat, Jayaram R.
Heterocycles, 1993 , vol. 35, # 1 p. 93 - 97
