1-环己基-2-(3-呋喃)-1H-苯并咪唑-5-羧酸合成路线 （共 6 条）
反应条件
sodium hydroxide in methanol; N,N-dimethyl-formamide
T=60°C; 2 h;
参考文献
Beaulieu, Pierre L.; Bousquet, Yves; Gauthier, Jean; Gillard, James; Marquis, Martin; McKercher, Ginette; Pellerin, Charles; Valois, Serge; Kukolj, George
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6884 - 6892
反应条件
1: aq. oxone / dimethylformamide / 4 h / 20 °C
2: 62.07 g / aq. NaOH / methanol; dimethylformamide / 2 h / 60 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Bousquet, Yves; Gauthier, Jean; Gillard, James; Marquis, Martin; McKercher, Ginette; Pellerin, Charles; Valois, Serge; Kukolj, George
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6884 - 6892
反应条件
1: aq. oxone / dimethylformamide / 4 h / 20 °C
2: 62.07 g / aq. NaOH / methanol; dimethylformamide / 2 h / 60 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Bousquet, Yves; Gauthier, Jean; Gillard, James; Marquis, Martin; McKercher, Ginette; Pellerin, Charles; Valois, Serge; Kukolj, George
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6884 - 6892
反应条件
1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C / Inert atmosphere
2.1: sodium dithionite / ethanol; dimethyl sulfoxide / 2.5 h / 90 °C / Inert atmosphere
3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 30 °C / Inert atmosphere
3.2: 0 °C / pH 4 / Inert atmosphere
View Scheme
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
反应条件
1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C / Inert atmosphere
2.1: sodium dithionite / ethanol; dimethyl sulfoxide / 2.5 h / 90 °C / Inert atmosphere
3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 30 °C / Inert atmosphere
3.2: 0 °C / pH 4 / Inert atmosphere
View Scheme
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
反应条件
1.1: sodium dithionite / ethanol; dimethyl sulfoxide / 2.5 h / 90 °C / Inert atmosphere
2.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 30 °C / Inert atmosphere
2.2: 0 °C / pH 4 / Inert atmosphere
View Scheme
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
