3-溴-4-氧代环己烷羧酸乙酯合成路线 （共 5 条）
反应条件
in ethanol 2 h; Reflux;
参考文献
ADVINUS THERAPEUTICS PRIVATE LIMITED; DESHPANDE, Anil; KANDALKAR, Sachin; NAIK, Keshav; DAVE, Bhavesh; BHUNIYA, Debnath; PALLE, Venkata
Patent: WO2011/95997 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/095997 A1
反应条件
1: T=150°C; 2 h; 2: With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; Further stages;
参考文献
Hack, Silke; Woerlein, Babette; Hoefner, Georg; Pabel, Joerg; Wanner, Klaus T.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1483 - 1498
反应条件
bromine in diethyl ether
T=-13°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BAKKER, Remko; BREITFELDER, Steffen; BUETTNER, Frank; EICKELMANN, Peter; FOX, Thomas; GRUNDL, Marc; LEHMANN-LINTZ, Thorsten; RIST, Wolfgang
Patent: WO2011/138427 A2, 2011 ;
Location in patent: Page/Page column 170 ;
WO 2011/138427 A2
反应条件
1: H2 / Ru/C / ethanol / 120 °C / 75005.9 Torr
2: CrO3, H2SO4 / acetone; H2O
3: Br2 / diethyl ether
View Scheme
参考文献
Maillard; Delaunay; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 457 - 460
反应条件
1: CrO3, H2SO4 / acetone; H2O
2: Br2 / diethyl ether
View Scheme
参考文献
Maillard; Delaunay; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 457 - 460
