4-羟基-7-三氟甲基-3-羧酸乙酯合成路线 （共 9 条）
反应条件
dowtherm T=250°C; 5 h;
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
Bi, Yingzhi; Stoy, Patrick; Adam, Leonard; He, Bin; Krupinski, John; Normandin, Diane; Pongrac, Ron; Seliger, Laurie; Watson, Andrew; Macor, John E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1577 - 1580
反应条件
1: T=120 - 150°C; 2: Heating;
参考文献
Venkat Lingaiah; Yakaiah; Ravi Kumar; Sathaiah; Chandra Shekhar; Raju; Shanthan Rao; Narsaiah; Murthy
Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 186 - 194
反应条件
1: 2 N NaOH / Heating 2: diphenyl ether / 1 h / Heating 3: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
1: With potassium hydroxide in water; ethylene glycol T=200°C; P=12137.6 - 13171.9 Torr; 0.5 h; Irradiation; 2: With hydrogenchloride in water; ethylene glycol pH=6;
参考文献
PFIZER INC.
Patent: WO2005/63739 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
WO 2005/063739 A1
反应条件
lithium hydroxide hydrate in methanol T=0°C; 2.16667 h;
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
hydrazine in ethanol 4 h; Reflux;
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
1: aqueous NaOH
2: 260 °C
3: phosphorus (V)-chloride; phosphoryl chloride / 130 °C
View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
