2-甲氧基-4-硝基苯甲酸甲酯合成路线 （共 21 条）
反应条件
nickel Hydrogenation;
参考文献
Clinton et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 592,595
参考文献
American Cyanamid Company
Patent: US5753648 A1, 1998 ;
US 5753648 A
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 2: dipyridinium dichromate / dichloromethane / 3 h / 40 °C View Scheme
参考文献
Bhusal, Ram Prasad; Yun Cho, Pyo; Kim, Soon-Ai; Park, Hyun; Kim, Hak Sung
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 5 p. 1461 - 1462
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 32, # 5 p. 1461 - 1462
反应条件
1: With sodium hydroxide in methanol; water T=60°C; 0.5 h; 2: With hydrogenchloride in methanol; water
参考文献
Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki
ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560
反应条件
1: aq.-ethanolic Na2CO3 2: iron-powder; aq.-ethanolic HCl View Scheme
参考文献
Nodzu et al.
Yakugaku Zasshi, 1959 , vol. 79, p. 1378,1379
Chem.Abstr., 1960 , p. 10936
反应条件
thionyl chloride in methanol; dichloromethane
参考文献
American Cyanamid Company
Patent: US5753648 A1, 1998 ;
US 5753648 A
反应条件
1: methyl 2-hydroxy-4-nitrobenzoate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=50°C; 1 h;
2: methyl iodide T=20 - 80°C; 4 h;
参考文献
SCHERING AG
Patent: WO2005/89815 A2, 2005 ;
Location in patent: Page/Page column 28 ;
反应条件
Oxonereg;; potassium hydroxide; disodium hydrogenphosphate; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; water; acetone
T=0°C; pH=7.5-8.5;
参考文献
Zabrowsky, Daniel L.; Moormann, Alan E.; Beck, Kenneth R.
Tetrahedron Letters, 1988 , vol. 29, # 36 p. 4501 - 4504
反应条件
thionyl chloride
T=20°C; 16 h;
参考文献
Wyeth
Patent: EP1021444 B1, 2003 ;
Location in patent: Page/Page column 24 ;
