N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺合成路线 (共 5 条)
反应条件
1: With 1,1'-carbonyldiimidazole in ethanol; water; toluene; acetonitrile T=17 - 27°C; 7.5 h; 2: With hydrogenchloride in water; toluene; acetonitrile 20.0833 h; 3: in ethanol; water; toluene T=0 - 45°C;
参考文献
US2005/85550 A1, ;
Page/Page column 8 ;
反应条件
toluene-4-sulfonic acid in methanol; water T=20°C; 18 h;
参考文献
US2005/85550 A1, ;
Page/Page column 8 ;