2-(2-氟-4-碘苯胺)-3,4-二氟苯甲酸合成路线 (共 6 条)
反应条件
lithium amide in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., , vol. 125, # 33 p. 8713 - 8718,6
反应条件
1: With 1,1'-carbonyldiimidazole in ethanol; water; toluene; acetonitrile T=17 - 27°C; 7.5 h; 2: With hydrogenchloride in water; toluene; acetonitrile 20.0833 h; 3: in ethanol; water; toluene T=0 - 45°C;
参考文献
US2005/85550 A1, ;
Page/Page column 8 ;
反应条件
thionyl chloride in N,N-dimethyl-formamide; toluene
T=50 - 65°C; 2 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/7616 A1, 2005 ;
Location in patent: Page/Page column 22 ;
WO 2005/007616 A1
反应条件
borane in tetrahydrofuran
T=20°C; 16 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/7616 A1, 2005 ;
Location in patent: Page/Page column 23 ;
WO 2005/007616 A1
反应条件
pyridine; 2,4,6-tri-fluoro-1,3,5-triazine in dichloromethane
T=0 - 20°C; 2.16667 h;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 178 ;
WO 2008/124085 A2