1: 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione With water; potassium hydroxide T=100°C; 66 h; 2: benzyl chloroformate in water; acetone T=0 - 20°C; 3: With hydrogenchloride in water pH=1;
参考文献
CHROMA THERAPEUTICS LTD.; DONALD, Alistair David Graham; MOFFAT, David Festus Charles; BELFIELD, Andrew James; NORTH, Carl Leslie; JONES, Stewart Andrew Wayne
Patent: WO2012/25701 A1, 2012 ;
Location in patent: Page/Page column 33 ;
WO 2012/025701 A1
1: aq. NaOH / 72 h / Heating 2: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
CHROMA THERAPEUTICS LTD.; DONALD, Alistair David Graham; MOFFAT, David Festus Charles; BELFIELD, Andrew James; NORTH, Carl Leslie; JONES, Stewart Andrew Wayne
Patent: WO2012/25701 A1, 2012 ;
Location in patent: Page/Page column 33 ;
WO 2012/025701 A1
anhydrous ammonium carbonate in ethanol
T=55 - 60°C;
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
