2-(4-氨基苯基)-1,3-噁唑-4-羧酸乙酯合成路线 （共 5 条）
反应条件
palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane
T=110°C; 18 h; Inert atmosphere;
参考文献
Verrier, Cecile; Martin, Thibaut; Hoarau, Christophe; Marsais, Francis
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7383 - 7386
反应条件
palladium diacetate; potassium carbonate; biphenyl-2-yl-di-tert-butyl-phosphane; 2,2,2-trimethylacetic acid in 1,4-dioxane
T=110°C; 18 h; Inert atmosphere; regioselective reaction;
参考文献
Theveau, Laure; Verrier, Cecile; Lassalas, Pierrik; Martin, Thibaut; Dupas, Georges; Querolle, Olivier; Van Hijfte, Luc; Marsais, Francis; Hoarau, Christophe
Chemistry - A European Journal, 2011 , vol. 17, # 51 p. 14450 - 14463
反应条件
1: ethanol / Heating
2: H2 / Pd/C / ethanol
View Scheme
参考文献
Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4670 - 4677
反应条件
1: 97 percent / aq. Na2CO3 / tetrahydrofuran / 0 °C
2: ethanol / Heating
3: H2 / Pd/C / ethanol
View Scheme
参考文献
Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4670 - 4677
反应条件
1: With lithium hydroxide in water; N,N-dimethyl-formamide
T=45°C; 12 h;
2: With hydrogenchloride in water
pH=5;
3: With copper(II) oxide in N,N-dimethyl-formamide
T=160°C; 70 h;
参考文献
Verrier, Cecile; Martin, Thibaut; Hoarau, Christophe; Marsais, Francis
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7383 - 7386
