2,4-二溴-3,5-二甲基噻吩合成路线 （共 14 条）
反应条件
1: 2,5-dimethyl-3,4-dibromothiophene With n-butyllithium; (PhSO2)2S in diethyl ether T=-78°C; Metallation; 45 h; 2: 3,4-Dibromo-thiophene in hexane T=-78°C; Substitution; 2 h;
参考文献
Inaoka, Seiji; Collard, David M.
Journal of Materials Chemistry, 1999 , vol. 9, # 8 p. 1719 - 1725
反应条件
aluminum oxide; iron (III) hydroxide; ethylenediaminetetraacetic acid; dihydrogen peroxide in methanol; water T=50 - 55°C; 5 h; Mechanism;
参考文献
Russian Journal of Physical Chemistry A, , vol. 83, # 11 p. 1873 - 1878
反应条件
1: n-butyllithium / water 2: n-butyllithium View Scheme
参考文献
Milek, Magdalena; Witt, Alexander; Streb, Carsten; Heinemann, Frank W.; Khusniyarov, Marat M.
Dalton Transactions, 2013 , vol. 42, # 15 p. 5237 - 5241
反应条件
N-bromosuccinmide in chloroform
T=20°C; 1.5 h;
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 87 ;
US 6342610 B2
反应条件
bromine in chloroform
T=0°C; Substitution; 4 h;
参考文献
Inaoka, Seiji; Collard, David M.
Journal of Materials Chemistry, 1999 , vol. 9, # 8 p. 1719 - 1725
反应条件
1: 2,3,4,5-tetrabromothiophene With n-butyllithium in tetrahydrofuran; n-heptane
T=-78°C; 1 h; Inert atmosphere;
2: methyl halide in tetrahydrofuran; n-heptane
T=-78 - 20°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Tung, Dang Thanh; Tuan, Dang Thanh; Rasool, Nasir; Villinger, Alexander; Reinke, Helmut; Fischer, Christine; Langer, Peter
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1595 - 1609
反应条件
nBu4NPF6; benzoic acid in acetonitrile
T=20°C; Electrochemical reaction;
参考文献
Thiemann, Thies; Ohira, Daisuke; Arima, Kazuya; Sawada, Tsuyoshi; Mataka, Shuntaro; Marken, Frank; Compton, Richard G.; Bull, Steven D.; Davies, Stephen G.
Journal of Physical Organic Chemistry, 2000 , vol. 13, # 10 p. 648 - 653
反应条件
in dichloromethane-d2
T=20°C; 38 h; Irradiationsealed tube;
参考文献
Thiemann, Thies; Ohira, Daisuke; Arima, Kazuya; Sawada, Tsuyoshi; Mataka, Shuntaro; Marken, Frank; Compton, Richard G.; Bull, Steven D.; Davies, Stephen G.
Journal of Physical Organic Chemistry, 2000 , vol. 13, # 10 p. 648 - 653
反应条件
carbon disulfide; bromine
参考文献
Lecocq
Annales de Chimie (Cachan, France), 1948 , vol. <12> 3, p. 62,84
反应条件
1: copper (I)-cyanide
2: carbon disulfide; bromine
View Scheme
参考文献
Lecocq
Annales de Chimie (Cachan, France), 1948 , vol. <12> 3, p. 62,84
