2-甲氧基-5-硝基溴化苄合成路线 (共 14 条)
反应条件
sulfuric acid; acetic acid; sodium bromide T=28 - 85°C; 20 h;
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
Location in patent: Page/Page column 56-57 ;
反应条件
phosphorus tribromide in toluene T=40 - 100°C; 0.5 h; Inert atmosphere;
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C / Inert atmosphere 2: phosphorus tribromide / toluene / 0.5 h / 40 - 100 °C / Inert atmosphere View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1: potassium ethylate; methanol 2: aqueous HBr / 180 °C View Scheme
参考文献
Calvet; Mejuto
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1932 , vol. 30, p. 767,775
反应条件
1: aqueous H2SO4 / -10 - -5 °C 2: aqueous HBr / 180 °C View Scheme
参考文献
Calvet; Mejuto
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1932 , vol. 30, p. 767,775
反应条件
1: aqueous HCl; water; NaNO2 / anfangs unter Kuehlung, zuletzt auf dem Dampfbad 2: potassium ethylate; methanol 3: aqueous HBr / 180 °C View Scheme
参考文献
Calvet; Mejuto
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1932 , vol. 30, p. 767,775
参考文献
Calvet; Mejuto
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1932 , vol. 30, p. 767,775
反应条件
diethylzinc; tetrakis(triphenylphosphine) palladium(0) in hexane; N,N-dimethyl-formamide T=25°C; 1 h;
参考文献
Agrios, Konstantinos A.; Srebnik, Morris
Journal of Organic Chemistry, 1993 , vol. 58, # 24 p. 6908 - 6910
反应条件
1: 2-Methoxy-5-nitro benzyl bromide With hydrogen; triethylamine; palladium hydroxide on carbon in N,N-dimethyl-formamide
T=20°C;
2: 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione in isopropyl alcohol
T=70°C; 0.5 h;
3: in diphenylether; biphenyl
T=220°C; 3 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1724268 A1, 2006 ;
Location in patent: Page/Page column 63 ;