1: With chloro-trimethyl-silane; copper(I) thiophene-2-carboxylate; (R)-p-tol-BINAP in diethyl ether
T=-78°C; Inert atmosphere;
2: With hydrogenchloride in methanol; diethyl ether; water
Inert atmosphere; optical yield given as percent eeenantiospecific reaction;
1: With copper(I) thiophene-2-carboxylate; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl in hexane; dichloromethane
T=0°C; Inert atmosphere;
2: With hydrogenchloride in hexane; dichloromethane; water
Inert atmosphere; optical yield given as percent eeenantioselective reaction;
