5,6-二甲基-1-氧代-2,1,3-苯并恶二唑-1-鎓合成路线 （共 5 条）
反应条件
potassium hydroxide; sodium hypochlorite in quinoline; ethanol; water
参考文献
Mallory,F.B. et al.
Journal of the American Chemical Society, 1965 , vol. 87, p. 5433 - 5438
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C
2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min
3: toluene / 2 h / Heating
View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
2: conc. sulfuric acid / 0.25 h / 100 °C
3: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min
4: toluene / 2 h / Heating
View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: acetic acid / 0.25 h / Heating
2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
3: conc. sulfuric acid / 0.25 h / 100 °C
4: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min
5: toluene / 2 h / Heating
View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
in toluene
2 h; Heating;
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
