1-苄基-4-氨基-4-哌啶甲酸合成路线 （共 4 条）
反应条件
1: With water; sodium hydroxide T=80 - 108°C; Industry scale; 2: With hydrogenchloride in water T=10 - 23°C; pH=7 - 8; Industry scale;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; Dahmann, Georg; Fiegen, Dennis; Fleck, Martin; Hoffmann, Matthias; Klicic, Jasna; East, Stephen Peter; Napier, Spencer Charles R.; Scott, John
Patent: US2013/23502 A1, 2013 ;
Location in patent: Paragraph 0266; 0269-0270 ;
反应条件
1: 89 percent / H2O; ethanol / 12 h / 60 °C 2: 66 percent / lithium hydroxide / H2O / 40 h View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John
Patent: WO2012/101013 A1, 2012 ;
WO 2012/101013 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 19 - 29 °C / Cooling 1.2: 8 - 56 °C 2.1: dichloromethane; water / 0.58 h / Cooling with ice 3.1: potassium tert-butylate / 1,1-dimethylpropan-1-ol / 0.5 h / 20 °C / Inert atmosphere 4.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / Inert atmosphere View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; Dahmann, Georg; Fiegen, Dennis; Fleck, Martin; Hoffmann, Matthias; Klicic, Jasna; East, Stephen Peter; Napier, Spencer Charles R.; Scott, John
Patent: US2013/23502 A1, 2013 ;
反应条件
sodium carbonate in tetrahydrofuran; water
T=20°C; pH=8 - 9; 18 h;
参考文献
Jin, Feng; Gao, Dan; Wu, Qin; Liu, Feng; Chen, Yuzong; Tan, Chunyan; Jiang, Yuyang
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5694 - 5706
