17-氨基-3,6,9,12,15-五氧杂十七烷醇合成路线 （共 11 条）
反应条件
platinum(IV) oxide; hydrogen in methanol P=760.051 Torr; 2 h;
参考文献
Tamiaki, Hitoshi; Ogawa, Keishiro; Enomoto, Keisuke; Taki, Kazutaka; Hotta, Atsushi; Toma, Kazunori
Tetrahedron, 2010 , vol. 66, # 9 p. 1661 - 1666
反应条件
1.1: 63 percent / Ag2O / CH2Cl2 / 48 h 2.1: 92 percent / NaN3 / dimethylformamide / 2.5 h / 110 °C 3.1: triphenyl phosphine / tetrahydrofuran / 10 h / 0 - 20 °C 3.2: 98 percent / water / tetrahydrofuran View Scheme
参考文献
Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503
反应条件
1.1: 92 percent / NaN3 / dimethylformamide / 2.5 h / 110 °C 2.1: triphenyl phosphine / tetrahydrofuran / 10 h / 0 - 20 °C 2.2: 98 percent / water / tetrahydrofuran View Scheme
参考文献
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; RUGA CORPORATION; GIACCA, Amato; LAI, Edwin; RAZORENOVA, Olga; CHAN, Denise; HAY, Michael, Patrick; BONNET, Muriel; SUN, Connie; TABIBIAZAR, Ray; YUEN, Po-wai
Patent: WO2013/155338 A2, 2013 ;
反应条件
hydrogenchloride; potassium tert-butylate in tetrahydrofuran; sodium chloride
参考文献
Kratz, Felix
Patent: US2003/185793 A1, 2003 ;
参考文献
Gartiser, Thierry; Selve, Claude; Mansuy, Laurence; Robert, Alain; Delpuech, Jean-Jacques
Journal of Chemical Research, Miniprint, 1984 , # 9 p. 2672 - 2691
反应条件
1: 81 percent / sodium azide / acetonitrile / 32 h / Heating 2: 56 percent / triphenylphosphine; water / tetrahydrofuran / 5 h View Scheme
参考文献
Zych, Andrew J.; Iverson, Brent L.
Journal of the American Chemical Society, 2000 , vol. 122, # 37 p. 8898 - 8909
反应条件
hydrazine in methanol 3 h; Heating;
参考文献
Takahashi, Teruki; Shiyama, Takaaki; Hosoya, Ken; Tanaka, Akito
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 447 - 450
反应条件
1.1: NaH / dimethylformamide / 2 h / 50 °C 2.1: 1.34 g / AcOH / tetrahydrofuran; H2O / 4 h / 20 °C 3.1: PPh3 / pyridine / 2 h / 20 °C 3.2: conc. NH4OH / pyridine / 2 h / 20 °C View Scheme
参考文献
Buijsman, Rogier C.; Basten, Jan E. M.; Dreef-Tromp, Cornelia M.; Van Der Marel, Gijsbert A.; Van Boeckel, Constant A. A.; Van Boom, Jacques H.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1881 - 1890
反应条件
1.1: 71 percent / DMAP / pyridine / 16 h / 20 °C 2.1: NaH / dimethylformamide / 2 h / 50 °C 3.1: 1.34 g / AcOH / tetrahydrofuran; H2O / 4 h / 20 °C 4.1: PPh3 / pyridine / 2 h / 20 °C 4.2: conc. NH4OH / pyridine / 2 h / 20 °C View Scheme
参考文献
Buijsman, Rogier C.; Basten, Jan E. M.; Dreef-Tromp, Cornelia M.; Van Der Marel, Gijsbert A.; Van Boeckel, Constant A. A.; Van Boom, Jacques H.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1881 - 1890
反应条件
1.1: 1.34 g / AcOH / tetrahydrofuran; H2O / 4 h / 20 °C 2.1: PPh3 / pyridine / 2 h / 20 °C 2.2: conc. NH4OH / pyridine / 2 h / 20 °C View Scheme
参考文献
Buijsman, Rogier C.; Basten, Jan E. M.; Dreef-Tromp, Cornelia M.; Van Der Marel, Gijsbert A.; Van Boeckel, Constant A. A.; Van Boom, Jacques H.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1881 - 1890
