4-(1,4-二甲基-1-乙基)戊基酚合成路线 （共 26 条）
反应条件
1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve 2: lithium diisopropyl amide / tetrahydrofuran / -78 °C 3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); isopropylamine / 3.5 h 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C 5: zinc / water; isopropyl alcohol / 26 h / 40 °C View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
1: TPAP; NMO / CH2Cl2 / 20 °C 2: 85 percent / LDA / tetrahydrofuran / -78 °C 3: 79 percent / Pd(PPH3)4; CuI; i-PrNH2 / 20 °C 4: 89 percent / TBAF / tetrahydrofuran / 20 °C View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
1: petroleum ether; MnO2 / <30 2: aluminium tert-butylate; benzene 3: zinc; benzene 4: iodine; petroleum ether / Behandeln des erhaltenen all-trans-Retinsaeure-aethylesters mit wss.-aethanol. Kalilauge unter Stickstoff bei Lichtausschluss View Scheme
参考文献
Matsui et al.
Journal of Vitaminology, 1958 , vol. 4, p. 190,192
反应条件
manganese(IV) oxide in hexane
参考文献
BEIERSDORF AF,
Patent: US2007/189984 A1, 2007 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: TPAP; NMO / CH2Cl2 / 20 °C
2: 85 percent / LDA / tetrahydrofuran / -78 °C
3: 79 percent / Pd(PPH3)4; CuI; i-PrNH2 / 20 °C
View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
in methanol
17 h; Ambient temperature;
参考文献
Ito, Masayoshi; Katsuta, Yuko; Yamano, Yumiko; Tsukida, Kiyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 8 p. 987 - 994
