5-苯乙基-[1,3,4]噻二唑-2-胺合成路线 （共 2 条）
反应条件
1: With trichlorophosphate T=75°C; 0.5 h; 2: With water 4 h; Reflux;
参考文献
Guan, Peng; Sun, Feng'E; Hou, Xuben; Wang, Feng; Yi, Fan; Xu, Wenfang; Fang, Hao
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3865 - 3872
反应条件
1: 72.3 percent / Dowtherm A / 1 h / 120 - 130 °C 2: 93.7 percent / conc. HNO3 / acetic acid / 2 h / Ambient temperature 3: 1.) POCl3, 2.) PhNEt2 / 1.) 70 - 90 deg C, 2.) 70 - 90 deg C, 3 h 4: 90.2 percent / conc. aq. NH4OH / dioxane / 0.25 h / 60 °C 5: tin, conc. aq. HCl / dioxane / Heating 6: conc. HCl, NaNO2 / H2O / 1 h View Scheme
参考文献
Suzuki; Miwa; Aibara; Kanno; Takamori; Tsubokawa; Ryokawa; Tsukada; Isoda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 357 - 363
