2-氨基-5-(4-氯苄基)-1,3,4-噻二唑合成路线 (共 2 条)
反应条件
1: With phosphorus tribromide T=60°C; 16 h; 2: With ammonia in water pH=9;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/104524 A1, 2008 ;
Location in patent: Page/Page column 56-57 ;
WO 2008/104524 A1
反应条件
sulfuric acid T=80°C; 7 h; Cooling with ice;
参考文献
Dhepe, Sharad; Kumar, Sujeet; Vinayakumar; Ramareddy, Sureshbabu A.; Karki, Subhas S.
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1550 - 1556