5-(4-氟苄基)-1,3,4-噻二唑-2-胺合成路线 （共 3 条）
反应条件
trichlorophosphate
0.75 h; Reflux;
参考文献
Badiger, Naveen P.; Khan, Ashraf; Kalashetti; Khazi
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1544 - 1549
反应条件
1: With sulfuric acid
T=-10 - 0°C; 3 h;
2: With sodium hydroxide in water
T=-10 - 0°C;
参考文献
SANOFI; Fett, Eykmar; Mougenot, Patrick; Namane, Claudie; Nicolai, Eric; Philippo, Christophe
Patent: US2012/40984 A1, 2012 ;
Location in patent: Paragraph 0256; 0257 ;
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2.1: sulfuric acid / 3 h / -10 - 0 °C
2.2: -10 - 0 °C
View Scheme
参考文献
SANOFI; Fett, Eykmar; Mougenot, Patrick; Namane, Claudie; Nicolai, Eric; Philippo, Christophe
Patent: US2012/40984 A1, 2012 ;
