1: 56 percent / CuSO4 / benzene / 12 h / Ambient temperature 2: 95 percent / Et3NHF / tetrahydrofuran / 3 h / Ambient temperature 3: 80 percent / lithium perhydro-9b-boraphenalyl hydride / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temp., 12 h 4: 1.) 47-52percent aq. HF, 2.) 5percent aq. HCl / 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h View Scheme

1: 80 percent / lithium perhydro-9b-boraphenalyl hydride / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temp., 12 h 2: 1.) 47-52percent aq. HF, 2.) 5percent aq. HCl / 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h View Scheme

1: 82 percent / CrO3 / CH2Cl2 / 2 h / Ambient temperature 2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to r.t., 6 h 3: 99 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature 4: 91 percent / N,N-diisopropyloethylamine / CH2Cl2 / 12 h / Ambient temperature 5: 56 percent / CuSO4 / benzene / 12 h / Ambient temperature 6: 95 percent / Et3NHF / tetrahydrofuran / 3 h / Ambient temperature 7: 80 percent / lithium perhydro-9b-boraphenalyl hydride / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temp., 12 h 8: 1.) 47-52percent aq. HF, 2.) 5percent aq. HCl / 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h View Scheme

1: 91 percent / N,N-diisopropyloethylamine / CH2Cl2 / 12 h / Ambient temperature 2: 56 percent / CuSO4 / benzene / 12 h / Ambient temperature 3: 95 percent / Et3NHF / tetrahydrofuran / 3 h / Ambient temperature 4: 80 percent / lithium perhydro-9b-boraphenalyl hydride / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temp., 12 h 5: 1.) 47-52percent aq. HF, 2.) 5percent aq. HCl / 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h View Scheme

1: 95 percent / Et3NHF / tetrahydrofuran / 3 h / Ambient temperature 2: 80 percent / lithium perhydro-9b-boraphenalyl hydride / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temp., 12 h 3: 1.) 47-52percent aq. HF, 2.) 5percent aq. HCl / 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h View Scheme

1: 68.7 percent / lithium perhydro-9b-boraphenalylhydride / tetrahydrofuran / 0.25 h / -70 °C 2: 80.8 percent / Dowex 50 x 2 (H(1+)) ion-exchange resin / ethanol / 1 h / Ambient temperature View Scheme

hydrogenchloride; hydrogen fluoride 1.) acetonitrile, room temp., 30 min, 2.) THF, reflux, 20 h; Yield given. Multistep reaction. Title compound not separated from byproducts;

peracetic acid; sodium acetate in dichloromethane; acetic acid T=-78°C; 96 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;