1: With potassium permanganate; disodium hydrogenphosphate in methanol; water T=25°C; Continuous flow conditionsSonication; 2: With hydrogenchloride; sodium thiosulfate; sodium chloride in methanol; water; ethyl acetate

1: 2-fluoro-6-chloro benzaldehyde With hydroxylammonium sulfate in methanol T=20 - 40°C; 1 h; 2: With chlorine; sodium carbonate; triethylamine in methanol T=0 - 20°C; pH=~ 9.5; 24 h; Inert atmosphere; 3: acetoacetic acid methyl ester With sodium carbonate in methanol pH=~ 7 - 7.5;

potassium hydroxide in ethanol

1: (i) NH2OH, (ii) Cl2, CHCl3, (iii) /BRN= 506727/, MeOH 2: aq. KOH / ethanol View Scheme

1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 1.2: 2 h / 0 - 20 °C / pH 9 2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux View Scheme

1.1: chlorine / methanol / 0 - 5 °C 2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 2.2: 2 h / 0 - 20 °C / pH 9 3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux View Scheme

(i) SOCl2, (ii) NH3, acetone; Multistep reaction;