2,6-二氟-4-硝基苯甲醚合成路线 （共 15 条）
反应条件
fluorine in formic acid; acetonitrile T=0 - 10°C;
参考文献
Chambers, Richard D.; Skinner, Christopher J.; Thomson, Julie; Hutchinson, John
Journal of the Chemical Society, Chemical Communications, 1995 , # 1 p. 17 - 18
反应条件
potassium carbonate in acetone 6 h; Heating;
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
反应条件
1: 96 percent / HNO3 / acetic acid / 15 - 20 °C 2: 94 percent / K2CO3 / acetone / 6 h / Heating View Scheme
参考文献
Kirk
Journal of Heterocyclic Chemistry, 1976 , vol. 13, # 6 p. 1253 - 1256
反应条件
sulfuric acid; nitric acid
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
反应条件
1: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck 2: concentrated H2SO4; HNO3 View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
1: platinum / Hydrogenation 2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck 3: concentrated H2SO4; HNO3 View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
in methanol 2 h; Ambient temperature;
参考文献
Cervera; Marquet; Martin
Tetrahedron, 1996 , vol. 52, # 7 p. 2557 - 2564
反应条件
1: 19 percent / PCl5, p-tert-butylphenol / 1.) 130-140 deg C, 2 h, 2.) 230-240 deg C, 40 min 2: 2 percent / methanol / 2 h / Ambient temperature View Scheme
参考文献
Cervera; Marquet; Martin
Tetrahedron, 1996 , vol. 52, # 7 p. 2557 - 2564
参考文献
English; Mead; Niemann
Journal of the American Chemical Society, 1940 , vol. 62, p. 350,353
参考文献
Kirk
Journal of Heterocyclic Chemistry, 1976 , vol. 13, # 6 p. 1253 - 1256
