2-氟-3-氧-丁酸-1,4-二乙酯合成路线 （共 12 条）
反应条件
sodium hydride in diethyl ether
参考文献
Shahak,I.; Bergmann,E.D.
Journal of the Chemical Society, 1960 , p. 3225 - 3229
参考文献
Kul'chitskii,M.M. et al.
Journal of Organic Chemistry USSR (English Translation), 1973 , vol. 9, p. 852 - 856
Zhurnal Organicheskoi Khimii, 1973 , vol. 9, p. 827 - 832
反应条件
(i) aq. NH2OH*HCl, (ii) BaCO3, (iii) Al-Hg; Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 26, p. 1414 - 1420
反应条件
1: oxalic acid diethyl ester With sodium ethanolate in ethanol
0.25 h; Cooling with ice;
2: ethyl (R)-(+)-2-fluoroacetate in ethanol
T=20°C; Cooling with ice;
参考文献
Vardanyan, Ruben; Kumirov, Vlad K.; Hruby, Victor J.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 920 - 924
反应条件
in tetrahydrofuran; monofluoro-trichloromethane
T=-75°C; 0.0166667 h;
参考文献
Lerman, Ori; Rozen, Shlomo
Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 724 - 727
反应条件
diethyl ether; sodium ethanolate
参考文献
Blank et al.
Journal of the Chemical Society, 1955 , p. 2190,2192
Bl. Res. Coun. Israel, 1953 , vol. 3, p. 101
反应条件
sodium ethanolate in benzene
参考文献
Shahak,I.; Bergmann,E.D.
Journal of the Chemical Society, 1960 , p. 3225 - 3229
反应条件
pyridine
Knoevenagel - Doebner reaction; Heating;
参考文献
Vardanyan, Ruben; Kumirov, Vlad K.; Hruby, Victor J.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 920 - 924
反应条件
iodine; zinc in tetrahydrofuran
Reformatsky reaction; Heating;
参考文献
Vardanyan, Ruben; Kumirov, Vlad K.; Hruby, Victor J.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 920 - 924
参考文献
Shahak,I.; Bergmann,E.D.
Journal of the Chemical Society, 1960 , p. 3225 - 3229
