反应条件
1: 2-bromo-α,α,α-trifluorotoluene With iodine; magnesium in tetrahydrofuran Grignard reaction; Inert atmosphereReflux; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran T=20°C; Grignard reaction; 3 h; Inert atmosphereCooling with ice;
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
