2,5-二甲基-4-硝基-2H-吡唑-3-羧酸合成路线 （共 5 条）
反应条件
sulfuric acid; nitric acid
T=60°C; 4 h; Inert atmosphere;
参考文献
Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5097 - 5104
反应条件
potassium hydroxide in methanol
Heating;
参考文献
Baraldi; Leoni; Cacciari; Manfredini; Simoni; Bergomi; Menta; Spinelli
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4329 - 4337
反应条件
sulfuric acid; nitric acid
T=55°C; nitrodeiodination; 1 h;
参考文献
Tret'yakov; Vasilevsky
Russian Chemical Bulletin, 1996 , vol. 45, # 11 p. 2581 - 2584
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 17 h; Inert atmosphere;
2: With ammonia; water in tetrahydrofuran; acetone
T=20°C; 16 h;
参考文献
Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5097 - 5104
反应条件
1: SOCl2 / 3.5 h / Heating
2: aq. NH4OH / acetone
3: 60 percent / H2 / Raney Ni / methanol; H2O
View Scheme
参考文献
Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5097 - 5104
