1: With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl in tetrahydrofuran T=-55°C; 1.5 h; Inert atmosphere; 2: With 1,2-dibromo-1,1,2,2-tetrachloroethane in tetrahydrofuran T=-55 - 20°C; Inert atmosphere; regioselective reaction;

phosphorus oxytribromide T=150°C; 2 h;

phosphorus tribromide 6 h; Heating;

sodium carbonate; Pd(Ph3P)4 in ethylene glycol dimethyl ether Suzuki coupling; 32 h; Heating;