2-氯-3,4-二氨基吡啶合成路线 （共 20 条）
反应条件
hydrogen; nickel in ethanol T=20°C; P=760.051 Torr; 4 h;
参考文献
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Patent: WO2007/47793 A2, 2007 ;
Location in patent: Page/Page column 87 ;
反应条件
methylamine in ehanol T=90°C; 2 h;
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
hydrogenchloride; tin(ll) chloride T=90°C; 2 h;
参考文献
Dvorakova, Hana; Holy, Antonin; Votruba, Ivan; Masojidkova, Milena
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 3 p. 629 - 648
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 3 h / 20 °C 2: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 4: trifluoroacetic acid / acetic acid / 24 h / 140 °C 5: diphenyl phosphoryl azide / 1,3-dimethyl-imidazolidin-2-one; toluene / 2 h / 140 °C 6: 140 °C 7: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 8: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1: diphenyl phosphoryl azide / 1,3-dimethyl-imidazolidin-2-one; toluene / 2 h / 140 °C 2: 140 °C 3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 4: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 2: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 2: trifluoroacetic acid / acetic acid / 24 h / 140 °C 3: diphenyl phosphoryl azide / 1,3-dimethyl-imidazolidin-2-one; toluene / 2 h / 140 °C 4: 140 °C 5: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 6: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1: trifluoroacetic acid / acetic acid / 24 h / 140 °C 2: diphenyl phosphoryl azide / 1,3-dimethyl-imidazolidin-2-one; toluene / 2 h / 140 °C 3: 140 °C 4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 5: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 3: trifluoroacetic acid / acetic acid / 24 h / 140 °C 4: diphenyl phosphoryl azide / 1,3-dimethyl-imidazolidin-2-one; toluene / 2 h / 140 °C 5: 140 °C 6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 7: methylamine / ehanol / 2 h / 90 °C View Scheme
参考文献
Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi
Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 0 - 23 °C 1.2: 120 °C 1.3: pH 7 2.1: hydrogen bromide; acetic acid / 90 °C 2.2: 20 °C / pH 7 / Cooling with ice View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
WO 2011/113802 A2
