4,7-二羟基-1,10-菲啰啉合成路线 （共 7 条）
反应条件
in diphenylether T=260°C; 0.5 h;
参考文献
Altman, Ryan A.; Koval, Erica D.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6190 - 6199
反应条件
1.1: 2 h / 100 °C 1.2: 77 percent / 1 h / 100 °C 2.1: 86 percent / diphenyl ether / 0.5 h / 260 °C View Scheme
参考文献
Altman, Ryan A.; Koval, Erica D.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6190 - 6199
反应条件
1: 4,7-diol-1,10-phen With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil T=0°C; 0.5 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil T=20°C; Inert atmosphere;
参考文献
Liu, Xiang; Li, Xiaoyong; Chen, Yu; Hu, Yimin; Kishi, Yoshito
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6136 - 6139
反应条件
1: POCl3 / 2 h / Heating 2: 16.7 g / methanol / 24 h / Heating View Scheme
参考文献
Altman, Ryan A.; Buchwald, Stephen L.
Organic Letters, 2006 , vol. 8, # 13 p. 2779 - 2782
反应条件
trichlorophosphate 2 h; Heating;
参考文献
Altman, Ryan A.; Koval, Erica D.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6190 - 6199
反应条件
phosphorus tribromide; phosphorus pentabromide
参考文献
Schmittel, Michael; Ganz, Andrea
Synlett, 1997 , vol. 1997, # 6 p. 710 - 712
反应条件
sodium hydride 1.) DMF, 25 deg C, 30 min, 2.) DMF, 60 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Stroemberg, S.; Oksman, M.; Zhang, L.; Zetterberg, K.
Acta Chemica Scandinavica, 1995 , vol. 49, # 9 p. 689 - 695
