3-(2-氨基-苯基氨基)-5,5-二甲基-环己-2-烯酮合成路线 （共 9 条）
反应条件
hydrogenchloride; sodium hydroxide; oxygen 1.) DMSO; Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 31, # 1 p. 1 - 4
反应条件
in toluene
Heating / refluxdean-stark trap;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2007/26024 A2, 2007 ;
Location in patent: Page/Page column 53; 110 ;
WO 2007/026024 A2
反应条件
toluene-4-sulfonic acid in benzene
1.5 h; Reflux;
参考文献
Vatolina; Andin
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 3 p. 408 - 411
反应条件
acetic acid in isopropyl alcohol
0.666667 h; Heating;
参考文献
Kolos; Yurchenko; Orlov; Shishkina; Shishkin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559
反应条件
1: 86 percent / pyridine; benzene / Ambient temperature
2: 86 percent / polyphosphoric acid / 1 h / 120 - 130 °C
3: 76 percent / sodium borohydride / 1 h / Ambient temperature
View Scheme
参考文献
Matsuo; Yoshida; Ohta; Tanaka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 4057 - 4062
反应条件
in dichloromethane
Ambient temperature; Yield given;
参考文献
Eynde, J. -J. Vanden; Mayence, A.; Maquestiau, A.; Anders E.
Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 9 p. 801 - 806
反应条件
in isopropyl alcohol
Heating;
参考文献
Kolos; Yurchenko; Orlov; Shishkina; Shishkin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559
反应条件
in dichloromethane
Ambient temperature; Yield given;
参考文献
Eynde, J. -J. Vanden; Mayence, A.; Maquestiau, A.; Anders E.
Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 9 p. 801 - 806
反应条件
in isopropyl alcohol
Heating;
参考文献
Kolos; Yurchenko; Orlov; Shishkina; Shishkin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559
