(R)-3-(N-BOC-N-甲氨基)吡咯烷合成路线 （共 4 条）
反应条件
hydrogen; 5 palladium over charcoal in ethanol T=20°C; P=2585.81 Torr; 44 h;
参考文献
Pfizer Limited
Patent: US2007/185075 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
US 20070185075 A1
反应条件
ammonium formate; palladium 10 on activated carbon in methanol; water 5 h; Heating / reflux;
参考文献
PALAU PHARMA, S. A.
Patent: WO2009/77608 A1, 2009 ;
Location in patent: Page/Page column 101-102 ;
WO 2009/077608 A1
反应条件
1: dichloromethane / 18 h / 0 - 20 °C 2: ammonium formate / water; methanol / 5 h / Reflux View Scheme
参考文献
PALAU PHARMA, S.A.; CARCELLER GONZALEZ, Elena; VIRGILI BERNADO, Marina; SOLIVA SOLIVA, Robert; FERRER COSTA, Carles
Patent: WO2011/76878 A1, 2011 ;
WO 2011/076878 A1
反应条件
1: dichloromethane / 18 h / 0 - 20 °C 2: ammonium formate / water; methanol / 5 h / Reflux View Scheme
参考文献
PALAU PHARMA, S.A.; CARCELLER GONZALEZ, Elena; VIRGILI BERNADO, Marina; SOLIVA SOLIVA, Robert; FERRER COSTA, Carles
Patent: WO2011/76878 A1, 2011 ;
WO 2011/076878 A1
