N*1*-苄基-4-氯-苯-1,2-二胺合成路线 （共 7 条）
反应条件
1: K2CO3 / dimethylformamide / 4 h / 110 - 120 °C
2: H2 / 10percent Pd/C / tetrahydrofuran / 3 h / 2280 Torr
View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Labeaga, Luis; Rodes, Rosa
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 586 - 593
反应条件
1: K2CO3 / dimethylformamide / 4 h / 110 - 120 °C
2: H2 / 10percent Pd/C / tetrahydrofuran / 3 h / 2280 Torr
View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Labeaga, Luis; Rodes, Rosa
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 586 - 593
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Xue, Ding; Long, Ya-Qiu
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4727 - 4734
反应条件
1: ethanol / 5 h / Reflux
2: SnCl2·2H2O / ethanol / 5 h / 20 °C
View Scheme
参考文献
Banoglu, Erden; Caliskan, Burcu; Luderer, Susann; Eren, Goekcen; Oezkan, Yagmur; Altenhofen, Wolfram; Weinigel, Christina; Barz, Dagmar; Gerstmeier, Jana; Pergola, Carlo; Werz, Oliver
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3728 - 3741
反应条件
1: water / 1 h / 100 °C
2: indium; hydrogenchloride / water / 1 h / 100 °C
View Scheme
参考文献
Kommi, Damodara N.; Jadhavar, Pradeep S.; Kumar, Dinesh; Chakraborti, Asit K.
Green Chemistry, 2013 , vol. 15, # 3 p. 798 - 810
反应条件
2: zinc; aq.-ethanolic HCl
View Scheme
参考文献
Rao; Ratnam
Proceedings - Indian Academy of Sciences, Section A, 1958 , vol. 47, p. 77,79
反应条件
1: With chloro-trimethyl-silane in N,N-dimethyl-formamide
Heating;
2: With water in N,N-dimethyl-formamide
T=20°C; 1 h; sonification; Further stages.;
参考文献
Ryabukhin, Sergey V.; Plaskon, Andrey S.; Volochnyuk, Dmitriy M.; Tolmachev, Andrey A.
Synthesis, 2006 , # 21 p. 3715 - 3726
