3-(3-呋喃基)丙烯酸合成路线 （共 10 条）
反应条件
pyridine T=80 - 90°C; 2 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=70°C; Inert atmosphere;
参考文献
Meng, Lingkui; Kamada, Yuko; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10048 - 10051
Angew. Chem., 2013 , vol. 125, # 38 p. 10232 - 10235,4
反应条件
1: 91.5 percent / thionyl chloride / benzene / 7 h / Heating 2: 67 percent / bis(triphenylphosphine)copper(I) tetrahydroborate, triphenylphosphine / acetone / 1 h / Ambient temperature 3: 70 percent / pyridine / 2 h / Heating View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1207 - 1209
反应条件
1: 67 percent / bis(triphenylphosphine)copper(I) tetrahydroborate, triphenylphosphine / acetone / 1 h / Ambient temperature 2: 70 percent / pyridine / 2 h / Heating View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1207 - 1209
反应条件
1: dichloromethane / 20 °C / |Inert atmosphere 2: lithium hydroxide hydrate / tetrahydrofuran; water / 70 °C / |Inert atmosphere View Scheme
参考文献
Meng, Lingkui; Kamada, Yuko; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10048 - 10051
Angew. Chem., 2013 , vol. 125, # 38 p. 10232 - 10235,4
反应条件
1: With triethylamine in acetone T=0°C; 0.666667 h; 2: With sodium azide in water; acetone T=0°C; 1 h; 3: With tributyl-amine in diphenyl Methane; benzene T=220°C; 1.5 h;
参考文献
ASKA Pharmaceutical Co., Ltd.
Patent: EP1724267 A1, 2006 ;
Location in patent: Page/Page column 128 ;
反应条件
1: With triethylamine in acetone Cooling with ice; 2: With sodium azide in water; acetone 1 h; Cooling with ice; 3: With tributyl-amine; diphenylamine T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
1: (COCl)2 2: 1.) Na2CO3, 2.) aq.NaOH / 1.) THF, water, 1 h, 2.) THF View Scheme
参考文献
Nagase, Hiroshi; Hayakawa, Jun; Kawamura, Kuniaki; Kawai, Kouji; Takezawa, Yuko; Matsuura, Hirotoshi; Tajima, Chiko; Endo, Takashi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 366 - 369
反应条件
hydrogen; palladium on activated charcoal in methanol
Catalytic hydrogenation; 5 h;
参考文献
Robertson, Andrew; Philp, Douglas; Spencer, Neil
Tetrahedron, 1999 , vol. 55, # 37 p. 11365 - 11384
反应条件
1: 60 percent / LAH / tetrahydrofuran / 20 °C
2: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Browder; Marmsaeter; West
Organic letters, 2001 , vol. 3, # 19 p. 3033 - 3035
