1-[(3-吡啶)甲基]哌嗪合成路线 （共 7 条）
反应条件
hydrogenchloride in water 16.5 h;
参考文献
Clasby, Martin C.; Chackalamannil, Samuel; Neustadt, Bernard R.; Gao, Xiaobang
Patent: US2006/135526 A1, 2006 ;
Location in patent: Page/Page column 23 ;
US 20060135526 A1
反应条件
hydrogenchloride; water in 1,4-dioxane; dichloromethane T=20°C; 5 h;
参考文献
Dong, Ming-Xin; Lu, Lu; Li, Haitao; Wang, Xiaohua; Lu, Hong; Jiang, Shibo; Dai, Qiu-Yun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3284 - 3286
反应条件
triethylamine in ethanol T=55°C; 12 h;
参考文献
Cai, Mingyi; Li, Zhong; Fan, Feng; Huang, Qingchun; Shao, Xusheng; Song, Gonghua
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 5 p. 2624 - 2629
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane; 1,2-dichloro-ethane / 20 h / 20 °C 2: hydrogenchloride; water / 1,4-dioxane; dichloromethane / 5 h / 20 °C View Scheme
参考文献
Hoveyda, Hamid R.; Roy, Marie-Odile; Blanc, Sebastien; Noel, Sophie; Salvino, Joseph M.; Ator, Mark A.; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1991 - 1996
反应条件
1: polymer supported perruthenate / toluene / 2 h / 80 °C 2: polymer supported cyanoborohydride / methanol; toluene / 72 h / Ambient temperature View Scheme
参考文献
Ley, Steven V.; Bolli, Martin H.; Hinzen, Berthold; Gervois, Anne-Geraldine; Hall, Beverley J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2239 - 2241
反应条件
polymer supported cyanoborohydride in methanol; toluene 72 h; Ambient temperature; Yield given;
参考文献
Ley, Steven V.; Bolli, Martin H.; Hinzen, Berthold; Gervois, Anne-Geraldine; Hall, Beverley J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2239 - 2241
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C;
参考文献
SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.
Patent: WO2003/87066 A1, 2003 ;
Location in patent: Page/Page column 10 ;
WO 03/087066 A1
