4-甲氧基-4'-甲基二苯胺合成路线 （共 37 条）
反应条件
1: p-toluidine With palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene T=20°C; 0.166667 h; Inert atmosphere; 2: 4-methoxyphenyl 1H-imidazole-1-sulfonate in toluene T=105°C; 17 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
1: p-toluidine With n-butyllithium in hexane; chlorobenzene T=0 - 20°C; 2: With zinc(II) chloride−TMEDA in hexane; chlorobenzene 3: Zn(C6H4-4-OMe)2 With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane in hexane; chlorobenzene T=80°C; 15 h;
参考文献
Nakamura, Yuki; Ilies, Laurean; Nakamura, Eiichi
Organic Letters, 2011 , vol. 13, # 22 p. 5998 - 6001
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene T=20 - 105°C; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
palladium diacetate; P(i-BuNCH2CH2)3N; sodium t-butanolate in toluene T=80°C;
参考文献
Urgaonkar, Sameer; Nagarajan; Verkade
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 452 - 459
反应条件
Cu(II) pivalate in dichloromethane T=40°C; 24 h;
参考文献
Rasmussen, L. Kyhn; Begtrup, Mikael; Ruhland, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6890 - 6893
反应条件
1: p-toluidine With n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique; 2: 4-methoxyphenyl magnesium bromide With N,N'-dimethyl-N,N'-propyleneurea; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane in tetrahydrofuran; hexane T=0 - 20°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Ilies, Laurean; Matsubara, Tatsuaki; Nakamura, Eiichi
Organic Letters, 2012 , vol. 14, # 21 p. 5570 - 5573,4
反应条件
PPA; trifluoroacetic acid in acetonitrile T=40°C; 3 h;
参考文献
Takeuchi, Hiroshi; Tateiwa, Jun-Ichi; Hata, Suguru; Tsutsumi, Keisuke; Osaki, Yoshinori
European Journal of Organic Chemistry, 2003 , # 20 p. 3920 - 3922
反应条件
1: With caesium carbonate; chloroacetyl chloride in N,N-dimethyl-formamide T=20°C; Smiles rearrangement; 0.5 h; 2: in N,N-dimethyl-formamide T=150°C; Smiles rearrangement; Microwave irradiation;
参考文献
Tian, Xiao; Wu, Ren-Min; Liu, Gang; Li, Zhu-Bo; Wei, He-Lin; Yang, Hao; Shin, Dong-Soo; Wang, Li-Ying; Zuo, Hua
Arkivoc, 2011 , vol. 2011, # 10 p. 118 - 126
反应条件
methoxybenzene; trifluoroacetic acid; ascorbic acid powder Ambient temperature;
参考文献
Shudo, Koichi; Ohta, Toshiharu; Okamoto, Toshihiko
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 645 - 653
反应条件
trifluoroacetic acid; zinc in methanol T=25°C; Schlenk techniqueInert atmosphere; Reagent/catalyst;
参考文献
Zhang, Li; Wang, Weibin; Fan, Renhua
Organic Letters, 2013 , vol. 15, # 8 p. 2018 - 2021
