1-(4’-溴苯氧基)-1-乙氧基乙烷合成路线 （共 4 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/811 A1, 2003 ;
Location in patent: Page 124-125 ;
WO 2004/000811 A1
反应条件
sodium iodide; potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide T=80°C;
参考文献
Seto, Masaki; Aramaki, Yoshio; Okawa, Tomohiro; Miyamoto, Naoki; Aikawa, Katsuji; Kanzaki, Naoyuki; Niwa, Shin-Ichi; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 577 - 590
反应条件
1.1: n-BuLi / diethyl ether; tetrahydrofuran; hexane / -78 °C 1.2: diethyl ether; tetrahydrofuran; hexane / 20 °C 2.1: aq. H2SO4 / diethyl ether; tetrahydrofuran; hexane View Scheme
参考文献
Seto, Masaki; Aramaki, Yoshio; Okawa, Tomohiro; Miyamoto, Naoki; Aikawa, Katsuji; Kanzaki, Naoyuki; Niwa, Shin-Ichi; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 577 - 590
