1-溴-4-(2-甲氧基乙氧基)苯合成路线 （共 9 条）
反应条件
1.1: n-BuLi / diethyl ether; tetrahydrofuran; hexane / 1 h / -78 °C 1.2: diethyl ether; tetrahydrofuran; hexane / 2 h / 20 °C 2.1: 7.17 g / aq. H2SO4 / diethyl ether; tetrahydrofuran; hexane / 0.5 h View Scheme
参考文献
Seto, Masaki; Aramaki, Yoshio; Okawa, Tomohiro; Miyamoto, Naoki; Aikawa, Katsuji; Kanzaki, Naoyuki; Niwa, Shin-Ichi; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 577 - 590
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C;
参考文献
Ghizzoni, Massimo; Wu, Jiang; Gao, Tielong; Haisma, Hidde J.; Dekker, Frank J.; George Zheng
European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 337 - 344
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in toluene
T=20 - 54°C;
参考文献
MERCK PATENT GmbH
Patent: WO2005/121091 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
dimethyl sulfate in tetrahydrofuran
参考文献
Britisch Biotech Pharmaceuticals, Ltd.
Patent: US5840974 A1, 1998 ;
US 5840974 A
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
T=80°C; 72 h;
参考文献
Seto, Masaki; Aramaki, Yoshio; Okawa, Tomohiro; Miyamoto, Naoki; Aikawa, Katsuji; Kanzaki, Naoyuki; Niwa, Shin-Ichi; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 577 - 590
反应条件
sodium iodide; potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
n-dodecyl sulfate; bromine in water
48 h; Yields of byproduct given;
参考文献
Jursic, Branko
Tetrahedron, 1988 , vol. 44, # 5 p. 1553 - 1558
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C
1.2: 60 percent / tetrahydrofuran / -78 - 20 °C
2.1: 95 percent / Et3SiH; TFA / CH2Cl2 / -78 - 20 °C
3.1: 98 percent / H2 / Pd/C / methanol; ethyl acetate / 735.51 Torr
View Scheme
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3670 - 3674
反应条件
palladium diacetate; Pd(tBu)3; sodium t-butanolate in toluene
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3670 - 3674
