反应条件
1: C19H23ClN2O*ClH With ammonia in water; toluene pH=8.5 - 9; 0.25 h; 2: sodium salt of the chloroacetic acid With potassium hydroxide in N,N-dimethyl-formamide T=0 - 10°C; 3: With hydrogenchloride in dichloromethane; water pH=4.3 - 4.8;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; DUBEY, Shailendra, Kumar; MANGLA, Amit; MASAND, Mukesh; VIR, Dharam
Patent: WO2012/101475 A1, 2012 ;
Location in patent: Page/Page column 16-17 ;