8-氯-10-(3-二甲基氨基丙基)吩噻嗪-2-醇合成路线 （共 17 条）
反应条件
1: NaOH, MeOH
2: (thionation)
3: Py*HCl
4: K2CO3 / acetone
5: NaH / toluene / 10 h / Heating
6: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: ZnCl2 / xylene
2: NaOH, MeOH
3: (thionation)
4: Py*HCl
5: K2CO3 / acetone
6: NaH / toluene / 10 h / Heating
7: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: NaOEt / ethanol
2: SnCl2, aq. HCl
3: (cyclisation)
4: Py*HCl
5: K2CO3 / acetone
6: NaH / toluene / 10 h / Heating
7: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: ZnCl2 / xylene
2: NaOH, MeOH
3: (thionation)
4: Py*HCl
5: K2CO3 / acetone
6: NaH / toluene / 10 h / Heating
7: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: NaH / toluene / 10 h / Heating
2: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: KOH / ethanol
2: NaOEt / ethanol
3: SnCl2, aq. HCl
4: (cyclisation)
5: NaH / toluene / 10 h / Heating
6: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: NaOEt / ethanol
2: SnCl2, aq. HCl
3: (cyclisation)
4: NaH / toluene / 10 h / Heating
5: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: Py*HCl
2: K2CO3 / acetone
3: NaH / toluene / 10 h / Heating
4: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: (thionation)
2: Py*HCl
3: K2CO3 / acetone
4: NaH / toluene / 10 h / Heating
5: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: SnCl2, aq. HCl
2: (cyclisation)
3: Py*HCl
4: K2CO3 / acetone
5: NaH / toluene / 10 h / Heating
6: aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
