11-甲氧基-11-氧代十一酸合成路线 （共 19 条）
参考文献
Durham; McLeod; Cason
Organic Syntheses, 1958 , vol. 38, p. 55
Full Text Show Details
Cason et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1187,1189,1190
反应条件
1: methanolic H2SO4
2: methanolic Ba(OH)2
View Scheme
参考文献
Durham; McLeod; Cason
Organic Syntheses, 1958 , vol. 38, p. 55
Full Text Show Details
Cason et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1187,1189,1190
反应条件
Oxonereg;; potassium hydroxide; sodium hydroxide; disodium hydrogenphosphate; water
1.) 65 deg C, 4 h, 2.) r.t., 4 h; Yield given. Multistep reaction;
参考文献
Ballini, Roberto; Curini, Massimo; Epifano, Francesco; Marcotullio, Maria Carla; Rosati, Ornelio
Synlett, 1998 , # 10 p. 1049 - 1050
反应条件
jones' reagent; boron trifluoride-tetrahydrofuran complex
1a) 0 deg C, 2 h, b) r.t., 2 h, 2) acetone, r.t., 3 h; Yield given. Multistep reaction;
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
1: 36.3 percent / Pb(OAc)4, pyridine, Cu(OAc)2 / benzene / 3 h / Heating
2: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h
View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
1: 36.3 percent / Pb(OAc)4, pyridine, Cu(OAc)2 / benzene / 3 h / Heating
2: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h
3: 100 percent / conc.H2SO4 / 4 h / Heating
4: 83 percent / LAH / diethyl ether / 2 h / Ambient temperature
5: 98 percent / PPTS / CH2Cl2 / 4 h / Ambient temperature
6: 1) n-BuLi, 2) HMPT / 1) THF, hexane, 10 deg C, 2) <25 deg C, 0.5 h
7: 92 percent / PPTS / ethanol / 70 °C
8: 98 percent / H2, quinoline / 5percent Pd/BaSO4 / methanol
9: 89 percent / PCC / CH2Cl2 / 1.5 h
View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
1: 36.3 percent / Pb(OAc)4, pyridine, Cu(OAc)2 / benzene / 3 h / Heating
2: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h
3: 100 percent / conc.H2SO4 / 4 h / Heating
4: 83 percent / LAH / diethyl ether / 2 h / Ambient temperature
5: 98 percent / PPTS / CH2Cl2 / 4 h / Ambient temperature
6: 1) n-BuLi, 2) HMPT / 1) THF, hexane, 10 deg C, 2) <25 deg C, 0.5 h
7: 92 percent / PPTS / ethanol / 70 °C
View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
thionyl chloride
T=50°C; 3 h;
参考文献
Kalgutkar, Amit S.; Crews, Brenda C.; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1692 - 1703
反应条件
1: 36.3 percent / Pb(OAc)4, pyridine, Cu(OAc)2 / benzene / 3 h / Heating
2: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h
3: 100 percent / conc.H2SO4 / 4 h / Heating
View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
